This quantitative-qualitative study aimed at ascertaining the behavioral consequences of substance use as influenced by stress among the 144 college students in selected state institutions in Iloilo City. Six (6) of these students provided qualitative data for the study. Conducted in December 2003, the purposive sampling technique was employed in the selection of the participants. This investigation utilized three instruments--a validated research-made Behavioral Consequences of Substance Use Checklist for College Students; the Self Test for Stress Signals; and the Family Dynamics APGAR Scale. Descriptive statistics used were frequency counts,percentage analysis,means,ranks, and standard deviation. For inferential statistics, the Wilcoxon-Mann Whitney U test, the Kruskal-Wallis One-Way Analysis of Variance By Ranks, and the Chi square test were used. The .05 alpha level was the criterion used for acceptance or rejection of the null hypotheses. Study results revealed that the most prevalent behavioral consequences of substance use among the students was "satisfactory coping response", while least prevalent was "aggressiveness". The levels of their aggressiveness (violence), withdrawal (passivity), and self-destructive behavior (suicidal) as a behavioral consequence of substance use were generally "low", while the levels of their academic (learning) problems and satisfactory coping responses were generally "moderate". The student had "low" level of stress. They differed significantly in their aggressiveness (violence) as a behavioral consequence of substance use when classified according to gender--in favor of male students and substance used--in favor of those who smoke,drink, and take drugs;and likewise in withdrawal (passivity) in favor of those with lower weekly allowance. Family functioning and self-destructive behavior as a behavioral consequence of substance use were significantly related. Gender and weekly allowance were significantly related. to satisfactory coping response as a consequence of substance use.