This action research sought to determine the effectiveness of the use of computer and statistical software (SPSS) as a strategy in teaching basic concepts in statistics among the Bachelor of Science in Nursing students at the University of San Agustin during the second semester of school year 2011-2012. Thirty four (34) students of BSN 2D were given a 30-item multiple choice pretest. The whole class were exposed to the use of the SPSS software package and were given prepared power point presentations on the topics in statistics during the early part of semester, contrary to what is prescribed in the course syllabus where hands on activities on the use of SPSS were given after the midterm examination. The researcher found after 3 weeks of intervention, the increase of performance of students who underwent varied teaching strategies with the use of computer and statistical software (SPSS) was found to be effective. A quasi-experimental method using the one-group pretest-posttest design was utilized. The z value was determined using the Wilcoxon Signed-RankS Test, at 0.05 level of significance was used. Results showed that the mean scores increased from 11.94 (below average performance) with the standard deviation of 3.07 in the pretest to 18.32 (above average performance) with the standard deviation of 4.35 in the posttest in a given 30-item test. A significant difference between the pre-intervention and post-intervention performance of students who were taught using varied teaching strategies with the use of computer and statistical software (SPSS). As to the students' perception of the Statistics subject after they have undergone exposure on the use of computer and statistical software (SPSS), their answers revealed that they realized that statistics after all is more interesting and fun to learn. They were able to appreciate further the very rich applications of statistics.