The purpose of the study the was to assess the anti-angigenic property of blue marine sponge (Xestospongia sp.) ethanolic extract on duck eggs. Three treatments were used in the study: 350 ug/ml sponge extract as treatment A, 700 ug/ml sponge extract as treatment B and Isotretinoin as positive control or treatment C. No interventions were done for the negative. A 2cm window was made to locate the chlorioallantoic membrane (CAM) of the duck egg after which, 2ml of albumen was extracted only to be replaced with the same volume of each treatment. Data were based on the number of blood vessels that formed post introduction to the reatments. A significant difference was observed after 48 hours. The mean blood vessels count of treatment A was 77, treatment B had a mean of 15 and treatment C had a mean of 3. All treatments were compared to the negative control which had a mean of 136. This suggests that the marine blue sponge extract does have antigiogenic properties.