This experimental study was conducted to screen the botonesan (Hyptis capitata Jacq.), bulak-manok (Adenostemma lavenia (Linn.) O. Kuntze), and damung-balang (Dactyloctenium aegyptium (Linn.) Richt.) crude plant extracts for their anti- angiogenic properties using the chick embryo in vivo chorioallantoic membrane (CAM) assay. The study made use of four treatments and three trials with three replicates per trial. Descriptive data analysis was used to describe anti-angiogenic activity based on the number of branch points on the vasculature of the CAM. Inferential data analysis subjected the mean of the numerical data derived from each set-up to One-Way Analysis of Variance (One-Way ANOVA) and Fisher’s Least Significant Difference (Fisher’s LSD) at a 0.05 level of significance. Based on the modified scale used, the three crude plant extracts exhibited anti-angiogenic activity, indicating that they have reduced the amount of vasculature on the chicken eggs’ CAM, while the negative control treatment did not. Statistical analysis has also revealed that significant differences exist between the anti-angiogenic activities of the crude plant extracts and the negative control treatment.