Health is a fundamental right of every person. However, various factors are inevitable leading to illness which could affect the well-being of individuals and apparently his performance in his field of work. This study entitled “Prevalent Signs and Symptoms of Illness among Residents along the Magapa – Suague River Basin, Janiuay, Iloilo highlights on the signs and symptoms of illness experienced by residents. It is premised that residents experience signs and symptoms which may be due to certain causes. Conducted last March 2014 and completed within the year, the study utilized descriptive research. Tools employed were frequency and percentages to determine the prevalent signs and symptoms of illness, while Z-test between two proportions was done in determining if there’s significant differences on the signs and symptoms felt by residents when classified as to sex and household respondents. Participants are the 25% of the randomly chosen households of the 16 barangays and were further randomly stratified. There were 628 total number of respondents. A researcher made questionnaire was used to obtain data. It was found out that the top three (3) prevalent signs and symptoms among residents when taken entirely and when grouped as to sex and household respondents are the same - cough, headache and fever. Z test results revealed that when grouped as to sex, the only sign and symptom having significant difference is “headache”, when fathers and mothers were tested , there was significant difference only on “cough”, between mothers and children, significant differences occur in symptoms like fever, head ache and stomach ache while z-test result between the fathers and children revealed that significant differences occur in symptoms of cough, head ache and flu.