Cigarette smoking is responsible for about five million deaths every year. This study aimed to determine the effect of anti-smoking audio visual, printed campaign materials and classroom demonstration on student knowledge and attitudes towards cigarette smoking. Grade 6 pupils of randomly selected school of Iloilo City were the participants to this study. A pre-test post-test one group design was used. The pre-test was administered before they were exposed to the different campaign materials and the posttest was given after viewing. Results showed that there is a significant improvement in knowledge about smoking. It further developed a negative attitude towards smoking when participants were exposed to anti-smoking campaign materials such as brochures, video clips, classroom demonstration and posters. Among the aforementioned campaign materials, study showed that the most effective material were video clips It is recommended that these campaign materials should be integrated in the school curricula of the K-12 to augment the anti-smoking campaign of the city government.