Writing notes by students has been greatly influenced by technology. Is keeping notebooks still relevant to record student learning, particularly in science classes? This study aimed to determine the students' achievement in biological science exposed to structured/ guided use science notebook and to open/ free use of science notebook in one semester. Ninety- five students comprised the two treatment groups- the structured/ guided use of science notebook and open/free use of science notebook. A researcher made Test on Animal Science Organ Systems determined the students' achievement. The pre- test scores of students exposed to structured use of science notebooks and to open use of science notebooks were "average", while both groups obtained "above average" scores during the post- test. There were significant differences between the pre- test scores of the students exposed to structured use and open use of science notebook. The same was true on the post- test scores of students. A higher mean was obtained by the structured use of notebooks group. Significant differences were observed in the pre- test and post- test scores of students exposed to each use of the science notebook group. Significant mean gain was obtained by the group with structured use of notebooks. Students preparation and exposure to structured use of notebooks have enhanced achievement in biology; hence, it could be a learning material even among college students.