This study aimed to determine the relationship of probable factors influencing the convictions of B.S. Biology Bioethics students of a state university towards bioethical issues. Specifically,it focused on determining whether case study discussion is effective as a strategy in improving comprehension of the four bioethics principles; whether the Bioethics course is effective in improving convictions of the students towards bioethical issues; on the probable predictors for comprehension of bioethics principle and convictions towards bioethical issues; and on determining model constructs of the predictors which are fit for the data. Two researcher-made validated instruments (convictions test for bioethical issues and comprehension test for the four bioethics principles), a survey-questionnaire, and two standardized tests(Otis-Lennon School Ability Test and the 16PF) were utilized to gather data from the 116 participants. The t-test for dependent samples was used to determine the effects of the case study discussion and the bioethics course. Step-wise multiple regression was utilized to determine predictors for comprehension and convictions among personal background factors, family background factors, global and primary personality factors based on 16PF, and mental ability. Path analysis models were then devised based on basis of the step-wise regression results and these were tested for goodness of fit using Structural Equation Modeling (SEM). Results of the comprehension tests showed that case study discussion was an effective tool in improving comprehension with a large effect size. Likewise, results of the convictions test showed that the Bioethics course was effective in improving convictions with a large effect size. The step-wise regression results showed that before exposure to case study discussion, verbal ability, warmth, and exposure to media were predictors for comprehension of the four bioethics principles. Predictors for convictions before intervention were identified as sex and openness to change. In the regression test for post-convictions, predictors were identified anxiety, self control, extraversion,liveliness, and perfectionism. Four corrected models were accepted, since they were able to reach at least 3 of the fit indices criteria of SEM.It was concluded that personal factors such as sex and some personality factors (openness to change, anxiety, self-control, warmth,liveliness, and perfectionism) are the contributors in convictions towards bioethical issues; not cognitive factors such as mental ability or comprehension of the four Bioethics principles.